Amicus Therapeutics For Genetic Diseases

Amicus Therapeutics is highly passionate about its work. It is a global company in the field of biotechnology. This company is into advanced therapies for treating rare as well as orphan diseases. The company has a highly robust development pipeline that includes treatments for several genetic diseases in humans.

Migalastat is considered by Amicus Therapeutics as its lead product candidate (MarketWatch). This can be considered as personalized medicine. It is in the last stages of its development. This will be used for treating individuals who are suffering from Fabry disease. This would require genetic diagnosis. Another product candidate is SD-101. Even this is in its last stages of development. This will be the first therapy to be marketed. It can be used for the genetic connective tissue disorder known as Epidermolysis Bullosa (EB). Amicus Therapeutics is making use of its biologics along with the Chaperone-Advanced Replacement Therapy platform technologies. These are being used for developing several enzyme replacement therapy products. These can be used for Fabry disease, besides Pompe disease, as well as several other Lysosomal Storage Disorders.

The lead biologics program of Amicus Therapeutics is ATB200/AT2221. This is a Pompe disease ERT. It is to be administered along with a pharmacological chaperone.

Amicus Therapeutics offers three clinical programs. In addition, they can leverage their biologics capabilities along with platform technologies that can help in expanding their pipeline.

The biologics capabilities of Amicus Therapeutics helps to provide a unique tool that can be used for developing Enzyme Replacement Therapy products that can be used for LSDs. Presently, Amicus Therapeutics has novel ERTs already that can be used for Fabry as well as Pompe disease. Now the technology platforms can be used for creating future opportunities that can lead to novel ERT being developed for other LSDs.

Currently, Amicus Therapeutics is researching a potential protein replacement therapy. This will be used in preclinical studies for the CDKL5 deficiency. Any kind of genetic mutations on this CDKL5 gene can lead to CDKL5 protein deficiency. This disorder manifests itself as persistent seizures. These begin in infancy itself. It can lead to a severe impairment that can take place in neurological development.
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Jason Hope Knows the Future of Business Technology

If a company wants to remain competitive in today’s market they must know how to effectively compete. Companies compete on many different levels. One the most important ways for a business to maintain its edge over the competition is by implementing a solid technology system. Without solid technology platform to provide the best way to deliver business services and products; a business will not be able to operate at its best.

Jason Hope is a business guru that understands how important technology is for any business. He is a technology guru that provides consultation services to organizations about the best technology trends for their operations. Hope strongly endorses the use of the internet of things. The internet of things is a concept that describes how various different machines, electronics and devices can be connected together through the use of the world wide web.

In business, this is a valuable technology platform that will make it easier for people do business within society. Consumers can use this technology to purchase products from their refrigerator when they run out of a certain food. They could even purchase more bathroom supplies by sending out an order from their computerized toilet. While this might seem unusual; it is not and more information click here.

The concept of the internet of things is already being implemented. Manufacturers are producing more appliances, machines and devices with the ability to connect through the internet. Businesses are now understanding how valuable this technology is. They can use it to provide market niche products to consumers who need them the most.

Businesses can also use the internet of things to allow consumers to make payments through their smart watches and even their automobile. This will allow businesses to provide people with more payment options. It will also help a company to sell more products and services. Jason Hope is really excited by this technology. He knows that it will improve the quality of life for everyone and Jason’s lacrosse camp.

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Joshua Tree: A Case Study in Conservation and Appreciation

Joshua Tree National Park stands apart from the other protected wildernesses of the California State Park system, simply because of its location. It sits at the intersection of three distinct ecosystems – the Mojave Desert, the Colorado Desert and the Little San Bernadino Mountains – in a protected space larger than the state of Rhode Island. From the high tablelands of the Mojave to the lower, warmer cactus forests in the eastern preserves, no other park in the state can boast the same diversity of ecosystems. Its standalone nature is symbolized in the Joshua trees from which it gets its name: the Joshua tree is confined almost exclusively to the Mojave and Joshua Tree National Park. Learn more:

While a popular spot for camping, hiking, and astronomy, in recent times Joshua Tree’s popularity has increased through rock climbing. The rock formations of the park consist of blocks of granite strewn across the valleys, some exceeding two hundred feet in height. With such colorful names as “Giant Marbles”, “Old Woman Rock” and “North Horror Rock”, the boulders provide thousands of climbing routes at all levels of experience; the formations are especially popular with the rock climbing community during the winter months when other climbing sites like Yosemite are snowbound. Learn more:

The overall effect of the Joshua Tree National Park, from its colossal formations of stone to its rugged, solitary Joshua trees, is that of an alien landscape untouched by the modern world. Nowhere else on the planet looks quite like it.

WildArk, formed with the mission to conserve, protect, and research the various wild places of the world, is dedicated to a similar appreciation of the natural world that the Joshua Tree National Park provides. Through travel recommendation, wildlife conservancies and eco-journalism, WildArk hopes to foster a similar admiration of the natural world that is so well exemplified by the conservation efforts of the California State Park system in Joshua Tree. Its balance of conservation, appreciation and human enjoyment provides a perfect example of the environmentally-conscious mindset and framework that WildArk maintains, in its work in Africa and around the globe. Learn more:


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Securus Technologies Builds Better Communication System for Inmates

Securus Technologies is a very powerful company that has been able to change the way that family and friends are now communicating with inmates on the inside. I certainly think that this company has been very effective when it comes to the communication software. It is so convenient for me because I don’t have to visit the prison anymore.


I love the video visitation because I have compared it to collect calls that I have received, and the cost is definitely lower. I feel like I am getting much better quality for my money when I sign up and schedule the video visitation. I think that this is the way that all people should be connecting with their friends that are incarcerated. I think that this is a best way to visit.


It is easy for me to have this type of visitation because I have access to a smartphone and a computer. It is so easy for me to connect to my friends on the inside when I have access to this type of hardware. Securus Technologies has been providing me with crisp and clear video. I know that other companies have this type of software platform, but I think that Securus has the clearest solution. This is definitely a better way to communicate.


I believe that Securus Technologies is also a great company for the prison system because it reduces the fraternization inside of the prison. I know that people are going to be impressed with what is happening with this company because it saves the prison system money. It also increases safety in the prison. These are benefits that cannot be overlooked. The technology upgrade is something that a lot of prisons will not always opt for, but many prisons systems need to upgrade for these reasons.


A portrait Of Sheldon Lavin

It can be hard to be as influential in an industry and yet remain out of the spotlight as long as Sheldon Lavin has managed. To this day he has still remained as one of the big movers and shakers, helping to propel forward the OSI Group.

Sheldon Lavin has managed to carve out a career from a totally opposite path than he started on. Originally working in finance, during the early 1970’s he decided to leave an industry he started in and move on into unfamiliar territory. From that point connected with the then leadership over at Otto & Sons, he decided to stay there and work with them to make what is now OSI Group into the blossoming business that it is today.


The thing that is so striking about Sheldon Lavin leadership and role as CEO of OSI Group, is that he retains complete voting rights for the company. That is a rare feat when talking about a company of the size and impact that OSI Group has on its associated industry. Even though he had no prior knowledge with the type of business that OSI Group is currently involved in, it is fair to say that he learned his trade quickly.

Sheldon Lavin chose to take the company in an even more global approach, in many ways leading it towards being the giant that it is today. His success has even been recognized internationally by the Vision World Academy in India. In 2016 Sheldon Lavin was presented with the Global Visionary Award. It is an award that honors people that have struggled, but persevered towards accomplishing their dreams. Which can certainly be said of him, as he has successfully guided OSI Group to a position of international competitiveness and being valued at over 6.1 billion dollars. The OSI Group is currently in the top 100 largest private companies in America.

All of his success is not only monetary in nature, as under his leadership OSI Group has gone on to earn several awards for environmental safety. In addition to that he has been involved in several charities.

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How Eva Moskowitz Became A Leader In The School Reform Movement

Eva Moskowitz has spent her professional career in the educational industry. She is the founder of Success Academy Charter Schools, a New York City chain of charter schools over which she leads as the Chief Executive Officer. She established the first Success Academy school in 2006 in the Harlem neighborhood. Eva Moskowitz’s leadership has led to there now being 32 schools that additionally located in Brooklyn, Manhattan, Queens, and the Bronx.

Serving 9,000 children that mostly come from low-income households, The Success Academy still outperforms even nearby affluent districts. Eva Moskowitz built a foundation at these schools that hold everyone accountable for achieving high educational standards, including the students themselves. The teacher’s work in a collaborative environment where they learn from each other the best practices in teaching children.

Eva Moskowitz was once the chair of the New York City Council Education Committee. She became a leader in school reform while investigating public schools and seeing how poorly they were run and their inability to properly educate children. During her time on the council, she exposed many scandals and problems at schools ranging from teacher practice to inadequate lighting in classrooms. She used the information she gathered while serving in this position to inform her choices at Success Academy in providing a better educational environment to properly foment learning.

Before founding the Success Academy, Eva Moskowitz was a professor at a number of universities including Columbia Unversity, Vanderbilt University, and the City University of New York. She earned her own college degrees at the University of Pennsylvania, where she received her bachelor of arts, and at John Hopkins University where she earned a Ph.D. in American History.

The ongoing crisis in education across the United States has become a well-known issue. Eva Moskowitz maintains that the problems aren’t what people usually point at, including poverty, African-Americans, and inner-cities. Rather, the problem is that the standards at public schools encourage mediocrity in both how teacher’s approach their material and the standards that students are held to. Her success at the Success Academy shows that every child can learn when given the opportunity.

To take a look at this businesswoman who is changing education like never before, take a look at her Wiki or pages.

Cameron Clokie’s Dream to Make an Impact on Bone Regeneration

Dr. Clokie is a teacher, scientist, entrepreneur and a surgeon. He is the CEO of Induce Biologics Inc which is a company that’s known to prioritize on innovative solutions on musculoskeletal reconstruction. His career began in 1985, where he received his Doctor of Dental Surgery and thereafter, he trained and specialized on the same.

He got his doctorate from McGill University in 1992 on interface development of dental implants on bone regeneration. He is a successful entrepreneur and a scientist who has served in several scientific boards as a consultant for many industrial partners and companies.

He became a maxillofacial and oral surgeon in 1998 then he was appointed as the head in maxillofacial surgery, he worked as Professor at University of Toronto on Maxillofacial and oral surgery.

In 1990 he tested BMP which is a tool that’s used in jaw surgery hence making a discovery of how one needs a lot of bones to regenerate it.

In 1999 Dr.Clokie achieved as the first man in the world to repair jawbone using BMP where he grinded the leg bones and arms of 40 cadavers so to have three milligrams of protein. Learn more about Cameron Clokie:

He stands out from other doctors because of his ability to use innovative approaches on jaws when it comes to surgical management. His technique involves resetting jaw’s skeletal clock making them develop as that of a baby.

He has published several papers both nationally and internationally and lectures internationally on regenerative medicine, future of Dentistry, oral health care and bone reconstruction and also on university-related technology transfer.

Cameron Clokie has successfully developed collaborators network that’s international that deals with trying to have knowledge on effects on bone regeneration by use of growth factor technologies.

Cameron Clokie is currently working as Head of Graduate Program in facial reconstruction at Oral and Maxillofacial Surgery which is located in Ontario and Toronto.

His main goal is to create a replacement on the need for autogenous bone grafts with bio implants which if it turns out to be successful it will help all patients that need bones surgical augmentation.

Dick DeVos; Giving Donations with No Strings Attached

Dick and his wife Betsy DeVos are a controversial couple in the world of philanthropy. This controversy originates from their enormous contributions to politics in the United States. During my research, I learnt that Dick and his wife Betsy had given donations amounting to $193 million. Nevertheless, as much as they are in the limelight for massive political donations, I discovered that much of their money goes to charitable causes as opposed to political ones.


For instance, Betsy revealed in her vetting process to become the US Education Secretary that the DeVos Family Foundation bequeathed $11.6 million to charitable ventures in 2015. This amount was twice more that they had donated to political campaigns for the past five years, $5.3 million. Therefore, I believe that they are genuine philanthropists and not led by political agendas.


Dick and Betsy are from families that have been actively involved in the Republican Party politics for many years. This also includes the couple’s four children who are also prominent philanthropists. In 2015, the DeVos family was ranked 24th on Forbes America’s Top Givers because of their total contributions amounting to $104 million in the same year. Moreover, I realised Forbes analysed their wealth only to reveal that the couple’s lifetime contributions approximated to 1.33 billion, which is a quarter if their entire fortune, $5.2 billion.


Dick and Betsy decided to reveal to the world the different causes they supported and the amount given to each cause in 2015. Education was a top priority for the high profiled couple who gave away $ 3 million to educational ventures and an extra $ 375,000 to societies that supported educational reforms. Other key areas included Public Policy ($1.3 million), Leadership and Development ($1.5 million, Health and Human services ($618,000), and Churches ($488,250).


About Dick DeVos


Dick DeVos attended the Northwood University for his undergraduate. He has had a vast career exposure working in countless executive posts at Amway, and NBA’s Orlando Magic. Currently, DeVos is the president and CEO of the Windquest Group. Beside business roles, Mr DeVos leads a number of community initiatives. For instance, I discovered that he is the founder of the Education Freedom Fund that has given put approximately 4,000 scholarships to disadvantaged children at the West Michigan Aviation Academy based in Michigan. DeVos has also sat on the State Board of Education.


Mr DeVos has won the National Champion sailor twice and is a qualified jet aircraft and helicopter pilot. Checking his Facebook page, I learnt that he is a public figure with over 18, 549 likes and has 18, 815 people following him. Most of his posts on this page include links to charitable ventures he is involved in, which are accompanied by several likes and comments. Mr DeVos has been married to Betsy for about 35 years, and they have four children and five grandchildren.

The Shrewd Investor, Hussain Sajwani

Global entrepreneurship success is a significant milestone for any one investor. For one to soar that high, he is required to have completely dedicated himself to the endeavor. Hussain Sajwani is an investor from the United Emirates who has done it. The great entrepreneur was born in 1956. His career history is remarkable, as he has garnered success in every venture he has undertaken.

Hussain attended his college education in Washington University. After that, he was hired as a Contracts Manager at GASCO Oil Company. At the firm, he learned critical management skills that would later be priceless in the management of his businesses. Not long after, he resigned to have a go at his entrepreneurship endeavors.

Hussain Sajwani, just like everyone else, wanted to have his enterprise and become his own boss. The thought of him running a catering unit in his hometown fascinated him. True to his wishes, he established a catering entity in 1982. He operated under the radar for almost ten years. In 1992, his name was on the lips of everyone who cared to monitor Dubai’s major investments.

His hospitality ventures had undergone a positive transformation, and their growth was tremendous. He built magnificent hotels and resorts to cater for the ever increasing number of people who visited the Emirates mostly for business expeditions.

Hussain Sajwani family investments never stopped growing. He committed his finances heavily on the capital and securities market both in Dubai and in the world market. His efforts led to the establishment of DICO Investments, which was his first investment company.

In addition, he ventured in the building and construction industry in Oman and established Al Amana Building Materials and Al Anwar Ceramic Tiles. His passion in catering never ceased, and he founded the AL Jazeira Services that has its presence all over the Middle East, Africa and CIS.

In 2002, Hussain Sajwani founded the firm that would place him on the global scale of investment, DAMAC Properties. The company specializes in the development of properties mostly in the residential, commercial, and leisure categories. It is the leading properties development firm in the Middle East, and its head offices are located in Dubai. Sajwani has partnered with Donald Trump and his organization towards construction of the monumental Trump International Golf Course in Dubai.

DAMAC Properties has developed a hospitality division, DAMAC Maison, to offer bespoke services to residents of its hotel apartments. Moreover, DAMAC owner, Hussain Sajwani, has donated two million AED towards the clothing of a million underprivileged children globally. DAMAC’s growth is attributed to its unique and diverse expertise utilized in all its projects.

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Brad Reifler Uses Investment Skills In His CEO Position

In the business world there are a variety of ways for people to climb the corporate ladder. One of the ways that people use to reach higher levels is by producing great results. In any business sector, it is hard to ignore success.

When people work hard and produce outstanding results, other people notice. This is usually a proven way to move up the corporate ladder. In the investment sector, there are things that make the sector vastly different than many other business sectors.

One of the things that makes the investment sector unique is that the sector is a result based sector. People who can produce numbers can move high within companies. There are many people who have moved into executive positions based on their performance and track record.

A powerful reason many people are able to move up in the investment sector is that numbers are easy to see and determine in the investment sector. Anyone can find out the top investment sales people or the top investment companies. The numbers are accessible to almost anyone.

A way that many people have become executives in the investment sector is by going the investment manager or sales route. Both of these routes give professionals the opportunity to demonstrate their capabilities. In addition, all levels of investment companies can see the professionals.

This makes the chance of the professionals being promoted much greater. There is a great amount of competition in the investment industry. The numbers that are produced from the competition is a measure that has been used to evaluate talent for many years.

An executive who has shown that great performance pays off with promotions and honors is Brad Reifler. The current CEO of a successful investment company, Brad Reifler is an investment professional who specializes in making investment selections for investors.

The great success that Brad Reifler has produced and continues to produce regarding investment selections has been a major reason behind his rapid rise in the investment industry.

According to Bloomberg, Brad Reifler has been able to take full advantage of the opportunities presented to him. He uses his ability to make great investment selections to help him catapult the company he runs to higher levels in the investment industry.

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